Time Restricted Eating on Human Health Part 5 - Effects on Circadian Clock | Modern Manual Therapy Blog - Manual Therapy, Videos, Neurodynamics, Podcasts, Research Reviews

Time Restricted Eating on Human Health Part 5 - Effects on Circadian Clock

Time Restricted Eating on Human Health Part 5 - Effects on Circadian Clock - themanualtherapist.com

Effects of Time Restricted Eating on Human Health

SERIES (5/6)


One mechanism hypothesized to explain the intrinsic effects of TRE, are it's actions on the body’s circadian rhythm.

The circadian system represents all the physiological processes involved in a 24-h cycle, such as:
  • Sleep/wake cycle.
  • Blood pressure.
  • Heart rate.
  • Hormone secretion.
  • Cognitive performance.
  • Mood regulation.
Limiting the time of food consumption seems to readjust the food intake with the circadian clock.

Several results support this hypothesis:
Adiponectin levels can increase with TRE (refer to last post), which actively regulates the action of the circadian system. In addition, a randomized controlled iso-caloric study showed eTRE affected the expression of six genes involved in circadian rhythm. Finally, studies have shown TRE produced a significant and durable improvement of sleep quality, duration and efficiency, which is directly linked to the enhancement of the circadian system.

Other beneficial effects of intermittent fasting:
  • Prevent cancer by lowering the IGF-1 level in animals and humans.
  • Decreased pro-inflammatory cytokines.
  • Increased expression of 4 genes involved in autophagy and longevity.
  • Increased secretion of BDNF, a protective factor against the development of neurodegenerative diseases.
  • In the elderly, an improvement in walking speed, a predictor of geriatric robustness.
  • Significant decrease in 8-isoprostane, a biomarker of oxidative stress.

6. Conclusions

Adafer et al. 2020. Food Timing, Circadian Rhythm and Chrononutrition: A Systematic Review of Time-Restricted Eating’s Effects on Human Health. Nutrients 2020, 12, 3770; doi:10.3390/nu12123770

Dalton Urrutia, MSc PT

Dalton is a Physical Therapist from Oregon, currently living and running the performance physiotherapy clinic he founded in London for Grapplers and Strength & Conditioning athletes. Dalton runs the popular instagram account @physicaltherapyresearch, where he posts easy summaries of current and relevant research on health, fitness, and rehab topics. 
Want to learn more or contact him?
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